摘要
目的：拟评价北曼哈顿多民族的前瞻性队列中卵圆孔未闭（PFO）引起缺血性卒中的风险。背景：PFO被认为与缺血性卒中风险增加相关，证据主要来自病例对照研究。在普通人群中，实际的PFO相关性卒中风险仍不明确。方法：研究对象为来自北曼哈顿研究（NOMAS）中1100例年龄〉39岁（平均68．7±10．0岁）的无卒中受试者，利用造影剂注射经胸二维超声心动图检查评估基线时的PFO。同时记录房间隔动脉瘤（ASA）。受试者接受每年随访。在校正已知的卒中危险因素后，评价PFO／ASA相关的卒中风险。
Objectives： We sought to assess the risk of ischemic stroke from a patent foramen ovale（PFO） in the multiethnic prospective cohort of northern Manhattan. Background： Patent foramen ovale has been associated with increased risk of ischemic stroke, mainly in case-control studies. The actual PFO-related stroke risk in the general population is unclear. Methods： The presence of PFO was assessed at baseline by using transthoracic 2-dimensional echocardio- graphy with contrast injection in 1,100 stroke-free subjects older than 39 years of age（mean age 68.7 ± 10. 0 years） from the Northern Manhattan Study（NOMAS） .
