期刊文献+

消化系恶性肿瘤患者血清转化生长因子β_1检测及临床意义 被引量:1

下载PDF
导出
摘要 目的:检测消化系肿瘤患者血清转化生长因子β1(transforming growth factor-beta,TGF-β1)的水平及探讨其临床意义。方法:采用酶联免疫吸附法测定102例消化系肿瘤患者和33例正常人的血清转化生长因子β1水平,其中胃癌56例,结直肠癌34例,胰腺癌12例。结果:3组肿瘤的血清转化生长因子β1水平显著高于对照组(Ρ<0.01)。结论:血清转化生长因子β1水平的升高有助于胃癌、结直肠癌、胰腺癌的诊断,有望作为新的肿瘤学检测指标在临床得到推广应用。
出处 《中国医药导报》 CAS 2007年第08Z期100-100,共1页 China Medical Herald
  • 相关文献

参考文献4

二级参考文献39

  • 1邵步云,陈谦学,刘刚,王军民,阮航,叶应湖.Smad_4和Smad_7在人脑胶质瘤中的表达及意义[J].肿瘤防治研究,2005,32(3):132-134. 被引量:4
  • 2[1]Nakashio T, Narita T, Akiyama S, et al. Adhesion molecules and TGFβ1 are involved in the peritoneal dissemination of NUGC-4 human gastric cancer cells[J]. Int J Cancer, 1997,70(5):612-618.
  • 3[2]Wu MS, Lee CW,Shun CT,et al. Clinicopathological significance of altered loci of replication error and microsatellite instability-associated mutations in gastric cancer[J]. Cancer Res,1998,58(7) :1494-1497.
  • 4[3]Imai Y,Tsurutani N,Oda H,et al. Genetic instability and mutation of the TGFβ receptor Ⅱ gene in ampullary carcinomas[J]. Int J Cancer, 1998,76(3): 407-411.
  • 5[4]Cardillo MR, Yap E. TGFβ1 in colonic neoplasia: a genetic molecular and immunohistochemical study[J]. J Exp Clin Cancer Res,1997,16(3) :281-288.
  • 6[5]Perry KT, Anthony CT, Case T, et al. Transforming growth factor β as a clinical biomarker for prostate cancer[J]. Urology,1997,49(1):151-155.
  • 7[9]Inoue T, Chung YS, Yashiro M, et al. Transforming growth factor β and hepatocyte growth factor produced by gastric fibroblasts stimulate the invasiveness of scirrhous gastric cancer cells[J]. Jpn J Cancer Res, 1997,88(2): 152-159.
  • 8[10]Oto M,Koguchi A,Yuasa Y. Analysis of a polyadenine tract of the transforming growth factor β type Ⅱ receptor gene in colorectal cancers by non-gel-sieving capillary electrophoresis[J].Clin Chem,1997 ,43(5 ) :759-763.
  • 9Slingerland J,Pagano M.Regulation of the CDK inhibitor p27kipl and its deregulation in cancer.J Cell Physiol,2000,183 (1):10~17.
  • 10Parekh C,Gama P,Wen X,et al.Transfoming growth factor β signaling is disabled early in human endometrial carcinogenesis concomitant with loss of growth inhition.Cancer Res,2002,62(10):2778~2790.

共引文献15

同被引文献10

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部