大肠癌异时陛肝转移的相关因素分析

Analysis of associated factor of heterochronic liver metastasis of colorectal cancer

目的 探讨影响大肠癌根治性切除术后出现肝转移的相关因素。方法 回顾性分析1992年1月～2001年12月行大肠癌根治术的87例患者的临床资料和随访资料，利用统计学软件计算无肝转移瘤的累积生存率，并做单因素和多因素分析。结果 术后1、3、5年累积无肝转移瘤生存率分别为90．7％、63．2％、63．2％。单因素分析显示，癌肿大小、浸润深度、病理组织学类型、分化程度、淋巴结转移是影响累积无肝转移瘤5年生存率的危险因素；多因素分析显示淋巴结转移和病理组织学类型是独立危险因素。结论 癌肿直径≥3cm、浸润深度达肌层、低分化及未分化癌、淋巴结转移是大肠癌异时性肝转移的危险因素。

Objective To investigate the associated factor of liver metastasis of colorectal cancer af- ter curative resection. Methods Clinical data of 87 cases with curative excision of colorectai cancer were analysed retrospectively. The cumate survival rate of no-liver metastatic tumor was analyzed by Kaplan-Meier method. Analysis of simple and multiple factor was evaluated by Kaplan-Meier Log-rank test and regression analysis. Results The cumulate 1,3 and 5 year survival rate of no-liver metastatic tumor were 90.7% ,63.2% and 63.2% ,respectively. Analysis of simple factor showed that the risk factors of the cumulate survival rate of no-liver metastatic tumor were tumor hulk,infiltrated depth, pathohistological type, differentiated degree and lymph node metastasis. Multiple factors analysis showed that the independent risk factors were pathohistological type and lymph node metastasis. Conclusions The risk factors of heterochronic liver metastasis of colorectal cancer are tumor hulk mot lower than 3 cm, infiltrated depth reached to muscular layer and lymph node metastasis.