帕金森病痴呆和路易体痴呆的临床与病理分析（附9例报告）

Clinical and pathological study in both Parkinson disease with dementia and dementia with Lewy bodies （ 9 cases report）

目的 研究帕金森病痴呆（PDD）及路易体痴呆（DLB）的临床特征和病理学基础。方法 对9例有痴呆伴有帕金森病症状患者的临床特征和病理学进行分析。结果 9例中5例临床诊断为PDD，2例为帕金森病（PD），1例为进行性核上性麻痹（PSP）和1例阿尔茨海默病（AD）。5例PDD的病理亚型是新皮质型3例，边缘型2例。结论 本研究显示PDD与DLB有相似的病理学基础。

Objective To study the clinical character and pathological substrate of both Parkinson＇s disease with dementia （PDD） and dementia with lewy bodies （DLB）. Methods The clinical character and pathological substrate of 9 patients who suffered from dementia and Parkinson syndrome were studied. Results 5 cases were diagnosed as PDD, 2 cases Parkison＇s disease（ PD, 1 case progressive supranuclear palsy （PSP） and 1 case Alzheimer disease （AD） , respectively. The pathological subtype of 5 patients with PDD was 3 patients with neocortical type and 2 patients with limbic type. Conclusion This study demonstrates the similar substrate of pathology in PDD and DLB.