肾脏短暂缺血对急性心肌梗死后心律失常的影响

The influence of renal infarction preconditioning on arrhythmias in acute myocardial infarction

目的明确肾脏短暂缺血预处理对急性心肌梗死(AMI)后心律失常的影响。方法观察单纯AMI组(A组)、和肾脏缺血预处理(RIP)组(B组)新西兰兔在AMI前后室性早搏发生率及QT间期离散度(QTd),并行心内电生理诱发室性心动过速(VT),对两组的指标进行比较,同时设置假手术组(C组)作对照。结果3组在手术前心律失常及QTd比较无显著性差异(P﹥0.05);C组手术前后心律失常及QTd比较无显著差异(P>0.05);在AMI后,B组室性心律失常及QTd明显小于A组(P<0.01)。结论RIP可减少AMI后室性心律失常的发生。

Objective To study the influence of renal infarction preconditioning （RIP） on arrhythmias after acute myocardial infarction （AMI）. Methods Arrhythmias and QT dispersion （QTd） of group A （rabbits without IP） and group B （rabbits with RIP） were measured after AMI, and electrophysiologic examination was made to induce ventricular tachycardia （VT）. The gained indexes of two groups were analyzed and compared with each other. Group C （shame operation） was served as control. Results Arrhythmias and QTd of each group had no significant changes before operation （p〉0.05）. arrhythmias and QTd of group C had no significant changes before and after shame operation （p〉0.05）. After AMI, The rate of ventricutar arrhythmla and QTd of group B were significant lower than that of group A （p〈0.01） . Conclusions The rate of ventricular arrhythmia and QTd in group B （with RIP） was significant lower than that of group A （without IP）.