IL-1Ra基因多态性在冠心病病人心血管事件中的作用

Effects of Interleukin-1 Receptor Antagonist Gene Polymorphism in Cardiovascular Events of Patients with Coronary Arterial Disease

目的探讨白细胞介素-1受体拮抗剂(interleukin-1receptor antagonist,IL-1Ra)基因多态性与冠心病患病率及心血管事件发生的关系。方法利用聚合酶链式反应(PCR)技术对220例冠心病患者及100例正常对照者IL-1Ra基因进行扩增;检测冠心病患者的高敏感性C反应蛋白、血清总胆固醇、甘油三酯、低密度脂蛋白和体重指数;所有冠心病患者随访12个月,了解患者在出院后1年内的心血管事件。结果冠心病患者和正常人的IL-1Ra基因多态性分布的差别没有统计学意义;出院后未发生心血管事件的冠心病患者Ⅱ型基因型携带率高于其他基因型。结论监测IL-1Ra基因多态性不能预测冠心病的发生;但其多态性中Ⅱ型基因对已患冠心病患者的预后有一定保护作用。

Objective To test the relationship between polymorphisms and the incidence of coronary artery interleukin-1 receptor antagonist （IL-1Ra） gene disease and the effect of IL-1Ra gene polymorphisms in prediction cardiovascular events. Methods Polymerase chain reaction was used in a series of 220 patients of coronary arterial disease （CAD） and a control group of 100 cases. A prospective 12 months follow-up was conducted in the CAD patients and cardiovascular events were recorded. Serum levels of total cholesterol, triglyceride, low density lipoprotein cholesterol, fibrinogen, hsCRP, and body mass index were measured. Results There was no significant difference between CAD patients and the control subjects in IL-1Ra gene polymorphisms. However, the IL-1Ra gene polymorphism was significantly higher among subjects in CAD patients without cardiovascular events than those with cardiovascular events. Conclusion It suggests that IL-1Ra gene polymorphisms can not predict the incident of coronary heart disease but might possess some protection for the patients of coronary arterial disease from cardiovascular events.