前胸部瘢痕疙瘩微血管的形态与分布

Microvascular Shape and Distribution in the Prothorax Keloid

目的:探讨前胸部瘢痕疙瘩微血管形态与分布的变化及其意义。方法:前胸部瘢痕疙瘩、正常皮肤标本经10%中性福尔马林液固定后常规石蜡包埋、切片,采用HE、CD34免疫组化微血管染色,观察微血管数量、分布和口径变化。结果:正常前胸部皮肤真皮乳头层血管网稀疏;真皮网状层微血管细小,分布比较均匀。瘢痕疙瘩微血管分布明显不均匀,乳头层微血管、网状层浅层微血管、网状层深层微血管分界清楚。和正常皮肤相比,瘢痕疙瘩浸润部乳头层微血管、网状层浅层微血管、网状层深层微血管丰富,微血管数量增加,微血管内径增大;老化部乳头层微血管、网状层深层微血管数量增加,微血管内径增大,网状层浅层微血管内径增大,微血管数量明显减少。和瘢痕疙瘩浸润部相比,瘢痕疙瘩老化部乳头层微血管、网状层深层微血管数量、微血管内径无明显变化,网状层浅层微血管数量减少,微血管内径无明显变化。瘢痕疙瘩浸润部、老化部网状层浅层微血管明显少于本组乳头层微血管和网状层深层微血管。结论:前胸部瘢痕疙瘩微血管不但数量和内径异常,而且分布异常。

Objective:To explore microvascular shape and distribution in the prothorax keloid.Method:Immunohistochemical method of CD34,HE was used for microvessel straining on the routinely paraffin-embedded sections of specimens of keloids,normal skin to observe the number,distribution and diameter of microvessel.Results:The microvessel net were fine in the normal skin tissue,the microvessel of reticular layer were distributed regularly.There were three microvessel net including papillar layer,superficial reticular layer and deep reticular layer in the keloids.The microvessel were more and larger in the all three layers in the invasive regions of keloids and in the papillar layer,deep reticular layer in the senile regions of keloid than in the normal skin,but in the superficial reticular layer in the senile regions of keloid the microvessel were larger and less.In the papillar layer,deep reticular layer of senile regions,the density and diameter were the same as invasive regions;the microvessel was significantly less in the superficial reticular layer in the senile regions of keloid than in the invasive regions of keloid tissues,but the diameters had no change.The number in the superficial reticular layer was less than in the papillar layer,deep reticular layer in the same group.Conclusion:There are marked distortion in the number,diameter and distribution of microvessel in the prothorax keloids.