摘要
目的:检测慢性乙型肝炎(乙肝)患者乙肝病毒脱氧核糖核酸(HBV-DNA),探讨HBV与胃粘膜病变的关系。方法:选择慢性乙肝并伴有慢性胃炎的患者58例(H组)及慢性胃炎但其血清HBV标志物(HBVM)和HBV-DNA均阴性对照组52名(C组),两组均进行胃镜检查,同时取胃粘膜,H组取空腹静脉血液,采用荧光定量聚合酶链反应(FQ-PCR)方法进行血清、胃粘膜HBV-DNA含量和血清HBVM检测。结果:H组血清和胃粘膜HBV-DNA阳性例数分别为38例(65.52%)和46例(79.31%),两者相比有显著性差异(χ2=6.125,P<0.05);两者HBV-DNA含量显著正相关。H组32例血清HBeAg阳性患者的血清和胃粘膜HBV-DNA均为阳性,而26例血清HBeAg阴性患者的血清和胃粘膜HBV-DNA阳性只有6例(23.1%)和14例(53.8%)。C组胃粘膜HBV-DNA全部阴性。胃镜下观察H组患者广泛存在胃窦炎,C组以慢性浅表性胃炎为主。结论:HBV存在于胃粘膜中,可能引起胃部的炎性损伤。
Objective:To investigate the relationship between HBV infection and gastric mucosa pathological changes.Method:Choosing 58 hepatitis B cases complicated with chronic gastritis as group Hepatitis(group H),and 52 chronic gastritis but both HBV serum marker(HBVM)and HBV-DNA negative cases as control(group C).Gastroscopies were performed on two groups,and get the samples of gastric mucosa.3 ml fasting hemospasia was collected from the patients of group H.HBV-DNA was detected in serums of group H cases as well as in gastric mucosa of two groups by fluorescence quantitative polymerase chain reaction(FQ-PCR).Besides,HBV serum marker(HBVM)was detected in the serums of group H.Results:The number of HBV-DNA positive cases is 38(65.6% in serum of group H)and 46(79.3% in gastric mucosa of group H)respectively,and the statistical difference of HBV-DNA positive rates of them is significance(χ2=6.125,P<0.05);In 32 HBeAg positive cases,HBV-DNA is also detected positive both in serums and gastric mucosa;In 26 HBeAg negative cases,the number of HBV-DNA positive cases is 6(23.1%)in serums and 14(53.8%)in gastric mucosa;In gastric mucosa of all cases of group C,the HBV-DNA is negative;The gastroscope reports that the cases in group H suffered antral gastritis extensively,whereas the primary pathological change in group C is chronic superficial gastritis.Conclusion:HBV can cause impairment to gastric mucosa.However,the extent of gastric mucosal injury doesn't depend on the content of HBV.
出处
《微循环学杂志》
2007年第3期44-45,共2页
Chinese Journal of Microcirculation
