血液灌流串联血液透析治疗尿毒症神经系统损害的疗效观察

Investigation of curative effect of hemodialysis combined with hemoperfusion on the treatment to uremia neuropathy

目的观察血液灌流(HP)串联血液透析(HD)治疗尿毒症神经系统损害的临床疗效。方法将24例有尿毒症神经系统损害病人随机分为治疗组(16例)和对照组(8例),对照组常规行血液透析治疗,治疗组行血液灌流串联血液透析(HP+HD)连续1个月。观察2组治疗前后临床症状体征及血β2-MG浓度变化。结果治疗组总有效率93.75%,治疗后β2-MG浓度明显下降。结论HP+HD治疗尿毒症神经系统损害明显优于单独使用HD治疗。

Objective To investigate the clinical efficacy of combined hemodialysis（HD）- hemoperfusion（HP） on the treatment of patients with uremic neuropathy. Methods 24 patients with uremic encephalopathy were randomly divided into 2 groups. Group 1 （16 patients） was treated with HP and HD, and group 2（8 patients） was only treated with HD for one month. The changes of clinical appearances and the plasma concentration of β2 - MG were observed and compared. Results The total effective rate of group 1 was 93.75%, and the plasma concentration of β2 - MG decreased significantly. Conclusion The efficacy of combined HP and HD on patients with uremic encephalopathy was better than that with HD only.