穴位埋线对抗精神病药物所致大鼠体重增加机理的研究

Mechanism of Catgut Embedding at Acupoint in Counteracting Rats Body Weight Increase Induced by Antipsychotic Drugs

目的:研究穴位埋线对抗精神病药物所致大鼠体重增加机理。方法:将36只大鼠随机分为对照组、空白组、治疗组,每组12只。用灌胃氯氮平的方式造模。治疗组采用医用羊肠线进行埋线治疗。观察大鼠体重、肾周脂肪以及血脂等相关指标。结果:大鼠体重埋线治疗前治疗组、对照组与空白组比较,差异有非常显著性意义(P<0.01);埋线治疗后治疗组与对照组比较,差异有显著性意义(P<0.05)。治疗组大鼠的存活率,与空白组比较,差异无显著性意义;与对照组比较,差异有非常显著性意义(P<0.01);甘油三酯(TG)、血清高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),治疗组与空白组比较,差异有显著性意义(P<0.05)。结论:穴位埋线对氯氮平所致大鼠体重增加具有显著疗效。

Objective:To explore the mechanism of catgut embedding at acu- point in counteracting rats body weight increase induced by antipsychotic drugs. Methods:Thirty-six rats were equally randomized into three groups:model group, blank control group and the treatment group.Rats model was induced by gastric infu- sion of clozapine.The treatment received catgut embedding at acupoint.After treat- ment,the changes of body weight,perirenal fat,blood lipid levels were observed. Results:The difference of body weight was significant in the three groups after treat- ment(P<0.01 compared with those before treatment),and also significant between the treatment and control group after treatment(P<0.05).The survival rate was higher in the treatment group,the difference being insignificant compared with the blank control group while significant compared with the model group(P<0.01). The differences of triglyceride(TG),high-density lipoprotein cholesterol(HDL- C)and low-density lipoprotein cholesterol(LDL-C)were significant between the treatment group and the blank control group(P<0.05).Conclusion:Catgut em- bedding at acupoint has a certain effect on counteracting the rats body weight increase induced by clozapine.