局部亚低温治疗对脑出血患者血脑屏障功能的影响被引量：2

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摘要目的探讨局部亚低温对脑出血患者血脑屏障的影响。方法将脑出血患者52例随机分为亚低温治疗组和常规治疗组;常规治疗组给予常规治疗,亚低温治疗组在常规治疗基础上给予局部亚低温治疗。检测治疗前后血脑屏障指数和血清髓鞘碱性蛋白(MBP)的变化,并进行统计学分析。另选腹外疝患者(空白对照组)10例腰椎麻醉时留取脑脊液并采静脉血。结果治疗前2治疗组患者血脑屏障指数和血清MBP浓度明显高于空白对照组,差异均有统计学意义(均P<0.05);治疗后5、10 d,亚低温治疗组血脑屏障指数及血清MBP浓度明显低于常规治疗组,差异均有统计学意义(均P<0.05);而治疗后10 d,亚低温治疗组血脑屏障指数及血清MBP接近正常水平,与空白对照组比较差异均无统计学意义(均P>0.05)。结论局部亚低温治疗可以减轻脑出血后细胞毒性对血脑屏障的损伤,从而减轻继发性脑损害。

作者王刚

机构地区山东省菏泽市立医院神经外科

出处《中国综合临床》北大核心 2007年第10期883-885,共3页 Clinical Medicine of China

关键词脑出血血脑屏障局部亚低温

分类号 R743.3 [医药卫生—神经病学与精神病学]

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