乙型肝炎病毒前S1抗原的实验室检测及其在临床上的应用

The clinical application of serum HBV-preS1 detection in individuals with hepatitis B viral infection

目的探讨前S1抗原的实验室检测及在乙型肝炎诊断中的临床意义。方法采用ELISA法检测429例乙型肝炎病毒感染者血清前S1抗原。结果在153例HBeAg阳性标本中前S1抗原阳性130例(84.9%),在抗-HBe阳性的177例标本中,前S1抗原阳性61例(34.5%),而99例HBeAg和抗-HBe全部阴性的标本中前S1抗原阳性25例(25.2%)。前S1抗原与HBeAg的阳性符合率高达84.9%。结论血清乙型肝炎病毒前S1抗原检测快捷方便,临床上可以作为乙型肝炎病毒感染复制及预后判断的重要血清指标。

Objective To study the assay of Pre-S1 antigen in serum and its clinical significance in hepatitis B. Methods Pre-S1 antigen in serum from 429 cases with hepatitis B virus infection were measured by ELISA. Results The 130 cases （84.9%） with Pre-S1 positive were found out of 153 cases with HheAg positive , and 61 cases （34.5%） were found in 177 cases with anti-Hhe positive. But the positive rate of Pre-S1 was only 25.2% （25/99） in 99 cases with both HheAg and anti-HBe negative. The positive rate between Pre-S1 and HheAg was highly matched （84.9 %）. Conclusion The determination of Pre-S1 antigen in serum is simple and rapid. It can he used as valuable index for hepatitis B virus infection.