番茄红素对实验性高脂血症小鼠的保护作用

Protective effect of lycopene on experimental hyperlipidemia mice

目的:研究番茄红素对实验性高脂血症模型小鼠血脂及抗氧化系统的影响。方法:48只6周龄雄性昆明种小鼠随机分为模型组,番茄红素低、中、高剂量组,三个剂量组分别预防性给予不同剂量番茄红素(5、10、20mg/kg.bw),两周后,以高胆固醇膳食诱导建立小鼠高脂血症模型,观察LP对小鼠血清总胆固醇(TC)、甘油三酯(TG)和高密度脂蛋白胆固醇(HDL-C)含量及肝脏超氧化物歧化酶(SOD)、过氧化氢酶(CAT)和丙二醛(MDA)含量的影响。结果:与模型组相比,各剂量组的番茄红素可不同程度地降低血清TC、TG浓度,提高血清HDL-C含量,并可上调肝匀浆中SOD和CAT活力,降低MDA含量(P(0.05)。结论:预防性给予番茄红素,可降低高脂血症小鼠血清脂质水平,提高肝脏抗氧化酶活力,对高脂血症的发生具有一定的抑制作用。

Objective ：To investigate the protective effect of lycopene （LP）on serum lipid and liver antioxidant status in hyperlipidemia mice. Methods ：48 km male mice ,6 weeks old, were divided randomly by weight into the model, low, middle and high LP（ 5,10,20, mg/kg bw）group. Two weeks later, all mice were fed with foods abundant in cholesterol for 2 weeks to establish model of hyperlipidemia. Serum total cholesterol （ TC ）, total triglycerides （TG） and high-density lipoprotein cholesterol（ HDL-C）, as well as liver superoxide dismutae（ SOD）, catalase （ CAT）, maleic dialdehyde （MDA） were determined for the four groups. Results：Compared with the model group, LP reduced serum TC,TG and liver MDA significantly. Furthermore, LP increased serum HDL-C and liver SOD, CAT activity （ P 〈 0. 05 ）. Conclusion： Pretreatment with LP inhibits initiation and development of hyperlipidemia effectively.