摘要
目的:分析抗癫痫药丙戊酸血药浓度的监测结果。方法:采用荧光偏振免疫法对我院226例/次丙戊酸血药浓度进行监测。结果:监测结果在一般参考治疗浓度范围内的占47.79%,平均浓度为(66.19±12.13)μg·mL-1,低于范围下限的占46.90%,高于范围上限的占5.31%。结论:监测结果达标情况不理想,应实施个体化给药,以达到治疗目的。
OBJECTIVE：To analyze the therapeutic drug monitoring results of valproic acid（anti -epileptic drug） .METHODS： The concentrations of valproic acid in 226 cases in our hospital were determined by fluorescence polarization immunoassay.RESULTS： The results showed that 47.79% were within the normal referenced concentration range, with average concentration at（66.19±12.13）μg·mL^-1, 46.90% were below the lower limit and 5.31% were above the upper limit.CONCLUSION：The monitoring results are far from satisfactory. It is advisable to adopt individualized administration so as to achieve the goal of treatment.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第23期1839-1840,共2页
China Pharmacy
关键词
丙戊酸
荧光偏振免疫法
血药浓度
Valproic acid
Fluorescence polarization immunoassay
Blood concentration
