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丙基硫氧嘧啶治疗Graves病时抗中性粒细胞胞浆抗体阳性的临床研究 被引量:1

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摘要 目的探讨丙基硫氧嘧啶治疗Graves病时与Graves病患者血清中抗中性粒细胞胞浆抗体(ANCA)的出现是否相关。方法我们分析了252名Graves病患者血清标本,其中应用丙基硫氧嘧啶治疗的患者168例,应用他巴唑治疗的患者50例,应用131碘治疗的患者34例。应用酶联免疫吸附测定(ELISA)试剂盒检测髓过氧化物酶(MPO)抗中性粒细胞胞浆抗体和蛋白酶3(PR3)抗中性粒细胞胞浆抗体。结果所有应用他巴唑治疗和131碘治疗的患者MPO-ANCA均为阴性,而168例应用丙基硫氧嘧啶治疗的患者中93例可检测到MPO-ANCA。随丙基硫氧嘧啶治疗时间的延长,MPO-ANCA阳性患者的比例增加,但与年龄、性别无关。结论丙基硫氧嘧啶本身与Graves病患者MPO-ANCA的产生有关。
出处 《中国地方病防治》 北大核心 2007年第4期314-315,共2页 Chinese Journal of Control of Endemic Diseases
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同被引文献9

  • 1周明宣,林玲,黄子扬,肖进益,陈小青.丙基硫氧嘧啶诱发抗中性粒细胞胞质抗体阳性小血管炎三例并文献复习[J].中华风湿病学杂志,2004,8(6):350-353. 被引量:8
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