摘要
目的:探讨浸润性乳腺癌分子亚型在中国人群中的分布,以用于判断临床预后和指导治疗。方法:回顾分析218例浸润性乳腺癌患者,根据雌激素受体(ER)、孕激素受体(PR)、人类表皮生长因子受体2(HER2)的水平划分为4个分子亚型。对比分析4型患者的分布比例、发病年龄、病理组织学分类、肿瘤最大径以及淋巴结转移等相关因素。结果:在4型中,luminal A型例数最多,共131例(60.1%);basal-like型共有63例(28.9%);luminal B型和HER2过表达型所占比例较少,均为12例(5.5%)。发病年龄以40岁~59岁年龄段发生乳腺癌例数最多,达到77.06%。HER2过表达型在50岁~59岁年龄段发病例数显著增高,与其余3组相比有显著性差异(P<0.05)。病理分类显示,浸润性导管癌最多,各型之间无显著性差异(P>0.05);从淋巴结阳性病例中,HER2过表达型和luminal B型多枚淋巴结转移比例更高(P<0.05)。肿瘤最大径分析显示,HER2过表达型和basal-like型病例肿瘤最大径2cm~5cm的比例较高,而luminal A型和luminal B型的肿瘤最大径多小于2cm(P<0.05)。结论:在4型中,luminal A型所占比例最高;HER2过表达型在50岁~59岁年龄段发病较多见;浸润性导管癌是最常见的病理组织类型;HER2过表达型和luminal B型多枚淋巴结转移情况更多发生;HER2过表达型和basal-like型肿瘤较luminal A型更大。
Objective :To investigate the distribution of different molecular subtypes of invasive breast cancer among Chinese people for clinical prognosis and directing treatment. Methods: Total of 218 invasive breast cancers were classified into four different subtypes according to estrogen receptor( ER), progestogen receptor(PR) and epidermal growth factor receptor2 ( HER2 ). The factors such as age, histopathological type, lymph nodal status, tumor size and distribution of molecular subtype were observed. Results: Luminal A cases were the majority, 131 cases (60.1%), basal -like was the second largest group, 63 cases (28.9%), luminal B and HER2 - overexpressing were two smallest groups, 12 cases(5.5% ) and 12 cases(5.5% ) respectively. Most subjects were of 40 -59 years old (77.06%). The HER2 - overexpressing breast cancer subtype patients,age was 50 to 59 ( P 〈 0.05 ), with significant difference to the rest subtype groups. Pathological analysis showed that invasive ductal carcinoma was more than invasive lobular carcinoma and other histological types( P 〉0.05 ). There were more lymph nodes metastasis in HER2 - overexpressing and luminal B groups ( P 〈 0.05 ). HER2 - overexpressing and basal - like subtype groups had more large- tumor- size cases (2cm to 5cm). While most cases in luminal A and luminal B subtyes were less than 2cm( P 〈0.05 ). Conclusion: Most cases of invasive breast cancers are luminal A subtype. Cases of HER2 - overexpressing are more in the age of 50 to 59 years old. Invasive ductal carcinoma are more often in the four subtypes. More lymph nodes metastasis happened in HER2 -overexpressing and luminal B subtypes. The tumor size of HER2 - overexpressing and basal - like subtypes are bigger than that of luminal A subtypes.
出处
《现代肿瘤医学》
CAS
2007年第8期1094-1097,共4页
Journal of Modern Oncology
基金
上海市重点学科建设资助项目(项目编号:T0304)
关键词
浸润性乳腺癌
分子亚型
临床研究
invasive breast cancer
molecular subtype
clinical study