^(99m)Tc-MIBI肺肿瘤显像与MRP表达的关系

Correlation between uptake of Tc-99m MIBI and expression of multidrug resistance-associated protein in primary lung cancer

目的:探讨原发性肺癌99mTc-MIBI显像与多药耐药相关蛋白(MRP)表达的关系。方法:对22例原发性肺癌行99mTc-MIBI早期(30min)、延迟(180min)显像,应用免疫组化方法检测手术标本中MRP表达水平,比较早期摄取比值(EUR)、晚期摄取比值(DUR)及储留指数(RI)与MRP表达的关系。结果:99mTc-MIBI早期、延迟显像阳性率分别为90.9%、81.8%,MRP表达阳性率27.3%;MRP表达阳性组与阴性组间与99mTc-MIBI的EUR、DUR及RI未见显著性差异。结论:原发性肺癌组织对99mTc-MIBI聚集、洗脱与MRP表达关系不大,应用99mTc-MIBI显像检测原发性肺癌MRP基因的表达临床价值不大。

Objective：To evaluate the relationship between the uptake of technetium -99m methoxyisobutylisonitrile （Tc -99m MIBI） and the expression of multidrug resistance - associated protein （MRP） in primary lung cancer. Methods： SPECT imaging was performed at 30rain and 180 rain after injecting Tc -99m MIBI in twenty - two patients with primary lung cancer. MRP expression was investigated by immunohistochemical study. The difference of the early uptake ratio （ EUR）, delayed uptake ratio （ DUR ） and retention index （ RI ） were compared between MRP （ - ） and MRP （ ＋ ）. Results： The positive rate of Tc -99m MIBI was 90.9% in early imaging and 81.8% in delayed imaging, and the positive expression rate of MRP was 27.3 %. There is no significant difference in EUR, DUR and RI between MRP （ - ） and MRP （ ＋ ）. Conclusion： The study suggests that there is no correlation between Tc - 99m MIBI and the expression level of MRP in primary lung cancer, and Tc - 99m MIBI has not much clinical value in predicting the expression of MRP.