NP和GP方案治疗晚期非小细胞肺癌临床对比研究的Meta分析

Meta analysis on curative effects of NP and GP schemes in the therapy of advanced non-small cell lung cancer

目的:采用Meta分析比较NP和GP方案治疗晚期非小细胞肺癌在有效率和骨髓抑制方面的优缺点。方法:检索有关NP和GP方案治疗晚期非小细胞肺癌的临床对比研究,分别对入选的研究进行文献评价,进行Meta分析。结果:从1994年～2005年共有12个研究入选,实验组413例。对照组共401例。分析结果显示:有效率RR值为1.05,95%可信区间为0.90～1.23,总体效应检验Z=0.63,P>0.05,无统计学意义;白细胞下降RR值为1.43,95%可信区间为1.26～1.61,总体效应检验Z=5.58,P<0.05,有统计学意义;血小板下降RR值为0.83,95%可信区间为0.72～0.96,总体效应检验Z=2.44,P<0.05,有统计学意义。结论:NP和GP方案均为治疗晚期非小细胞肺癌的有效方案。GP方案对白细胞的影响小而对血小板的影响大。敏感性分析和发表性偏倚的识别结果表明,本次Meta分析的结果稳定,可靠。

Objective：To investigate the effective rate and arrest of bone marrow （decrease of leucocytes, platelet） of neoadjuvant chemotherapy schemes NP and GP in the therapy of advanced non - small cell lung cancer by Meta analysis. Methods： After generally collection the clinical literatures published in domestic and overseas from 1994 to 2005 that reported on the effective rate and arrest of bone marrow （decrease of leukocyte, platelet） of neoadjuvant chemotherapy schemes NP and GP in the therapy of advanced non - small cell lung cancer, Meta analysis was performed are processed by Review Manager 4.2 program, selecting fixed or random model based on the heterogeneity test. Results： 12 literatures were selected for Meta analysis based on our including and excluding standers. There was no difference between the effective rates of NP and GP schemes, but decrease of leukocyte was greater in NP schemes, decrease of platelet was greater in GP schemes. Conclusion ： NP and GP schemes are effective in therapy of non - small cell lung cancer. Decrease of leukocyte and platelet are two adverse effects. Decrease of leukocyte is greater in NP schemes, decrease of platelet is greater in GP schemes.