新疆维吾尔族女性乳腺癌C-erbB-2和nm23表达和预后的关系

The relation between expression of C-erbB-2 and nm23 and prognosis in Uygurs women with breast cancer in Xinjiang,China

目的:探讨C-erbB-2、nm23在新疆维吾尔族女性乳腺癌的表达与临床病理因素的关系。方法采用S-P免疫组化方法,检测58例维吾尔族女性乳腺癌石蜡包埋组织和30例乳腺增生病变中C-erbB-2、nm23的表达情况。结果:58例维吾尔族女性乳腺癌组织中C-erbB-2、nm23蛋白阳性表达率分别为56.90%和70.70%,而在乳腺增生组织中的阳性表达率分别为13.30%和90.00%,与癌组织间存在显著差异(P<0.05)。C-erbB-2表达与临床病理特征之间无明显相关(P>0.05),nm23与临床分期、ER状态有关(P<0.05),而与肿瘤大小、腋淋巴结状态、病理类型、患者年龄、月经状况及PR状态无关。C-erbB-2和nm23的蛋白表达无相关(P>0.05)。结论:nm23低表达与维吾尔族女性乳腺癌的侵袭、转移及预后有关,可作为预测其临床预后的分子指标。

Objective：To explore the relationship between the expression of C - erbB -2 and nm23 genes and clinicopathological characteristics in Uygurs women with breast cancer in Xinjiang. Methods：The expressions of C - erbB - 2 and nm23 proteins were detected by immunohistochemical S - P method in 58 specimens of breast cancer tissues of Uygurs women and 30 non - tumor breast diseases specimens. Results： The positive rates of C - erbB - 2 and nm23 protein were 56.90 % , 70.70% in tumor tissues of Uygurs women and 13.30 % ,90.00 % in benign breast lesions respectively. There was significant difference between the positive rates of breast cancer and benign lesions （ P 〈 0.05 ）. Expression of C - erbB - 2 protein was not related with clinicopathological characteristics （ P 〉 0.05 ）. Expression of nm23 protein was related with clinical stage and status of ER （ P 〈 0.05 ） , but was not related with tumor size, status of involved axillary lymph nodes,type, age, menstruation and status of PR. There was no correlation be- tween the expression C- erbB- 2 and nm23 protein （P 〉 0.05 ）. Conclusion： The expression of nm23 protein with low frequency related to tumor invasion and metastasis progressing could be a molecular marker for predicting prognosis of the breast cancer of Uygurs women.