食管癌肿瘤细胞放疗后加速再增殖及相关治疗

The Treantment of accelerated repopulation of esophagus cancer cells after radiotherapy

放射治疗是食管癌的主要治疗方法之一。多年来一直沿用常规分割放疗方法。但单纯常规放射治疗食管癌的疗效一直无明显提高,大量的研究表明,食管癌常规放疗5年生存率低下的主要原因是食管癌放疗中肿瘤细胞产生加速再增殖。随着放射生物学的进展,国内外学者研究出许多克服肿瘤细胞加速再增殖的治疗方法,如加速超分割放射治疗、剂量-密度化疗、热疗以及各种放疗增敏剂的应用等,提高了食管癌的局部控制率和长期生存率。

Radiotherapy is one of the most efficient ways of esophagus cancer treatment. The conventional radiotherapy is constantly used for the past many years. But during a long time, the therapeutic effect of the simple conventional radiotherapy has no significant promotion. A great deal of researches indicate that the main reason is the accelerated repopulation of tumor cells in esophagus radiotherapy. With the development of radiobiology, scholars from all over the world have investigated lots of method overcoming the accelerated repopulation of tumor cells, in order to improve the local control and long term survival. Among these, there are accelerated hyperfraction radiotherapy, dose - dense chemotherapy, thermotherapy, application of various kinds of sensitizer and so on.