摘要
目的研究银屑病患者皮损内趋化性细胞因子受体CXCR3的表达及其临床意义。方法利用荧光定量聚合酶链反应法测定20例寻常型银屑病患者皮损内及17例正常对照者皮肤中CXCR3 mRNA的定量表达,采用直线相关回归分析方法分析CXCR3 mRNA的表达与银屑病病情严重程度(PASI)的关系。结果银屑病皮损内CXCR3 mRNA高于正常对照者皮肤内的表达水平(P<0.01)。银屑病皮损内CXCR3 mRNA的表达与患者病情严重程度呈显著的正相关(r=0.72465,P<0.01)。结论趋化性细胞因子受体CXCR3可能在银屑病的发病中起重要作用。
Objective To study the expression and clinical significance of chemokines receptor CXCR3 in psoriatic lesional skin. Methods Twenty adult patients with psoriasis vulgaris and 17 health people were sequentially chosen in this study. The production CXCR3 mRNA was measured by Fluorescence Quantitative Polymerase Chain Reaction Method. The relationship between CXCR3 and disease severity（PASI） was assessed by linear regression and correlation. Results Expression of CXCR3 mRNA in psoriasis lesional skin was higher than that in control group（ P 〈 0.01）. Expression of CXCR3 mRNA was markedly positive correlation with PASI（ r = 0.72465, P 〈0.01）. Conclusion Our data suggest an important role of CXCR3 in the development and advance of psoriasis vulgaris.
出处
《右江医学》
2007年第4期362-364,共3页
Chinese Youjiang Medical Journal
基金
2004年东莞市科技计划项目(东科函[2004]68号)
关键词
银屑病
趋化性细胞因子受体
CXCR3
荧光定量聚合酶链反应
psoriasis vulgaris
chemokines receptor
CXCR3
Fluorescence Quantitative Polymerase Chain Reaction Method
