原发性十二指肠癌临床特点及其微血管密度检测的意义

Clinical characteristics of primary duodenal carcinoma and meaning of micro-vessel density

目的分析原发性十二指肠癌的临床特点并探讨微血管生成与其生物学行为及预后的相关性。方法回顾性分析102例原发性十二指肠癌的临床资料并对76例癌标本及癌旁非癌组织行免疫组化S-P法微血管密度(MVD)检测。结果原发性十二指肠癌的高发年龄为40～60岁。黄疸、上腹疼痛、腹胀、消瘦为该组4大主要临床表现。MVD与十二指肠癌的发生、肿瘤大小、组织分化程度、浸润深度、转移、手术切除率及预后均有相关性。结论原发性十二指肠癌具有症状不典型、误诊率高及预后差等特点;CA50、CA19-9联合检测有助诊断;MVD与十二指肠癌生物学行为密切相关且影响预后。

[Objective] To analyze the clinical characteristics and investigate the relationship between microvessel density （MVD） and pathobiological behavior and prognosis in primary duodenal cancer （PDC）. [Methods] Chnical data of 102 patients with PDC was analyzed retrospectively. By using SP immunohistochemical method, MVD values in the samples from 76 patients with PDC were measured. [Results] The age of most patients was from 40 to 60 years old. Jaundice, abdominal pain, abdomen bulge and weight loss were common manifestations. MVD was related with PDC,s origin, tumor size, tissue differentiation, invading depth ,metastasis, operation rate and prognosis. [Conclusions] PDC had no characteristic manifestations, had high error diagnosis rate and bad prognosis; Combined determination of CA50 and CA19-9 was useful for the diagnosis; MVD was related to PDC,s biology behavior and affected its prognosis.