基于胃分泌指标的甘草泻心汤君药问题探讨

Discussion on the Sovereign Drug of Gancaoxiexin Decoction Based on Gastric Secretion Index

目的:从药效学角度探讨甘草泻心汤君药问题。方法:采用均匀设计法对甘草泻心汤进行拆方,测定各配比组方对胃酸含量、胃蛋白酶活性及胃黏液分泌的影响,针对实验数据应用MATLAB软件,建立药味与药效指标(胃酸、胃蛋白酶、胃黏液)的非线性影射模型,并应用该模型,分析甘草泻心汤中各药味在全方背景下的量效关系。结果:对正常大鼠胃蛋白酶分泌,甘草、黄芩、黄连、大枣、生姜具有促进作用;半夏、干姜、党参具有抑制作用。对大鼠胃酸分泌,干姜、黄芩、黄连、大枣、生姜具有促进作用;半夏具有抑制作用。对胃黏液分泌,黄芩、黄连、大枣、生姜有抑制作用。结论:本研究对于探讨甘草泻心汤君药问题具有一定参考价值。

Objective： To discuss the sovereign drug of GancaoXiexin decoction from pharmacodynamics. Method： GancaoXiexin decoction were disassembled according to the homogenous design. Detect the effects of analogous decoctions on gastric acid dosage,gastric pepsin activity and gastric juice secretion . Through case study on the experiment data by Matlab softrare , we established nonlinear mapping formula between ingredients and dosage index （gastric acid, gastric pepsin, gastric juice）. By applying this formula , we discussed dose - drug efficacy relations under the background of taste in a prescription. Result： Radix Glycytthizae, Radix Scutellariae, Rhizoma Coptidis, Fructrs Jujubae and Rhizoma Zingiberis Recens could increase gastric pepsin in rats , but Rhizoma Pinelliae, Rhizoma Zingiberis, Radix Codonopsis could reduce gastric pepsin in rats . Rhizoma Zingiberis, Radix Scutellariae, Rhizoma Coptidis , Fructrs Jujubae and Rhizoma Zingiberis Recens could increase gastric acid secretion in rats, while Rhizoma Pinelliae could re-duce gastric acid secretion in rats. Radix Seutellariae, Rhizoma Coptidis, Fruetrs Jujubae and Rhizoma Zingiberis Recens could reduce gastric juice secretion in rats. Conclution： This research is valuable for the question of GancaoXiexin decoction.