万拉法新与氟西汀治疗老年期抑郁症对照研究

A comparative study of venlafaxine and fluoxitine in the treatment of senile depression

目的比较万拉法新与氟西汀治疗老年期抑郁症的疗效和安全性。方法符合中国精神障碍分类与诊断标准第3版修订版(CCMD-3)的62例老年期抑郁症患者随机分为万拉法新组和氟西汀组进行4周的治疗,采用汉密顿抑郁量表(HAMD)评定临床疗效,在治疗前及治疗后1,2,4周进行评定。结果万拉法新组显效率为77.4%,氟西汀组显效率为71.0%,两组之间无显著差异(P>0.05)。万拉法新起效迅速,主要副反应为消化道症状、轻度头晕。结论万拉法新治疗老年抑郁症与氟西汀疗效相当,起效快,副作用较少。

Objective To compare the efficacy and side - effects of venlafaxine and fluoxetine in the treatment of Senile depression. Methods 62 cases of patients were randomly divided into two groups to receive venlafaxine and fluoxetine for 4 weeks. The efficacy were assessed by Hamilton Depression Scale（HAMD） before treatment and 1,2,4 weeks after treatment. Results Venlafaxine showed more rapid effects than fluoxetine after 1 and 2 weeks of the treatment, the scores of HAMD were lower than that of fluoxetine, which reduced significantly（P 〈 0.05 ）. The total effective rates for venlafaxine and fluoxetine were 77.4% and 71.0% respectively after 4 weeks of the treatment, there were no significantly difference between the two groups （P 〉 0.05 ）. The side effects of two groups were slight and have no differences. Conclusion Venlafaxine takes effect faster and has better effect and milder side efftects in patients with senile depression.