儿童感染性疾病凝血指标检测的临床意义

Clinical significance of the coagulation parameter in children with infectious disease

目的探讨儿童感染性疾病中,凝血功能变化对感染的诊断及转归的意义。方法取患儿感染期标本,分别以凝固法、发色底物法、免疫胶体金法等检测凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原含量(FIB)、凝血酶时间(TT)、抗凝血酶活性(AT:A)、D-二聚体(DD)等凝血及抗凝指标。结果感染患儿的凝血指标与正常对照组儿童间差异有统计学意义,特别是AT:A与DD的结果在弥散性血管内凝血(D IC)组与非D IC组中差异有统计学意义。结论各凝血指标特别是AT:A和DD的检测可作为D IC前期诊断和预后评估的指标。

Objective To investigate the dynamic changes of the coagulation function in children with infectious disease and its prognosis significance. Methods Blood levels of prothrombin time （ FF）, activated partial thromboplastin time （ APTT）, fibrinogen （ FIB ）, thrombin time （ TT）, antithrombin activity （ AT ： A ） and D-Dimer （ DD ） were tested by coagulation method, color substrate method and immunological colloidal gold method. Results The levels of these parameters were significantly different between the infected children and the normal children, especially AT：A and DD were distinguished between disseminated intravascular coagulation （DIC） group and non-DIC group. Conclusions Coagulation parameters, especial AT： A and DD, may be used for early diagnosis of Pre-DIC and evaluation of the prognosis.