硝苯吡啶缓释片的人体药物动力学及生物利用度

THE PHARMACOKINETICS AND BIOAVAILABILITY OF NIFEDIPINE SUSTAINED-RELEASE TABLETS IN YOUNG HEALTHY VOLUNTEERS

用HPLC法测定血中硝苯呲啶浓度,对进口的硝苯呲啶和国产的硝苯呲啶缓释片进行健康人药物动力学和生物利用度研究,所得数据经3P87软件处理.结果显示:硝苯呲啶以二室模型进行分布和消除,进口硝苯呲啶的生物利用度明显优于国产硝苯呲啶(P<0,05),消除半衰期长于国产硝苯呲啶(P<0.05).

The blood concentrations of two different nifedipine sustained-release tablets were determined by HPLC for studying on the pharmacokinetics and bioavailability in healthy volunteers. Disposed by 3P87 program, the conclusion showed: nifedipine was distributed and eliminated in two compartment model. Imported nifedipine was greater than native product in bioavailability and the elimination half time is longer than native product(P <0. 05).