丙戊酸镁对广泛性焦虑的辅助治疗作用

Accessory effect of magnesium valproate in treatment of generalized anxiety

目的:观察帕罗西汀联合丙戊酸镁治疗广泛性焦虑的疗效。方法:将60例广泛性焦虑患者随机分为两组,分别接受帕罗西汀联合丙戊酸镁(合用组)和帕罗西汀(单用组)治疗。疗程4周。分别于治疗前和治疗第1、2、4周末以汉密尔顿焦虑量表(HAMA)、临床疗效总评量表(CGI)评定疗效,治疗中出现的症状量表(TESS)评定药物不良反应。结果:治疗4周末,合用组HAMA评分显著低于单用组;合用组显效率显著高于单用组;两组不良反应均轻,发生率相仿。结论:帕罗西汀联合丙戊酸镁治疗广泛性焦虑有良好的疗效。

Objective：To observe the efficacy of paroxetine combined with magnesium valproate in the treatment of generalized anxiety. Method：60 patients with generalized anxiety were randomly divided into two groups, treated with paroxetine combined with magnesium valproate or with paroxetine only for 4 weeks. Effects and side effects were assessed with Hamilton anxiety rating scale （HAMA）, clinical global impression （CGI） and treatment emergent symptoms scale （TESS） before and after 1,2,4 weeks treatment. Results：At the end of 4th week, the score of HAMA were significantly lower in combined group than in single group. The side effects were mild and the occurrence rate were similar in beth groups. Conclusion： Paroxetine combined with Magnesium valproate has better efficacy in the treatment of patients with generalized anxiety.