280例儿童抗感染药物不良反应报告分析

An analysis of 280 case reports of children’s adverse drug reactions to antibiotics

目的:探讨儿童抗感染药物不良反应(ADR)特点,为临床合理用药提供参考。方法:对我院2006年收集到的280例抗感染药物ADR报告,建立数据库并进行统计分析。结果:10岁以下儿童发生不良反应较多;药物中以β-内酰胺类所致不良反应较多,ADR临床表现以皮肤损害为主。结论:应重视儿科临床药物不良反应的监测。

Objective： To investigate the general patterns and characteristics of ADR to antibiotics and to guide rational drug use. Methods： 280 cases of children＇s ADR to antibiotics collected from our hospital in 2006 were put into data base and analyzed. Results： Most patients who had ADR were teenagers less than 10 years and most cases of ADR were caused by β-lactam antibiotics. The clinical manifestation of most ADR was skin lesion. Conclusions： Most attention should be paid to children＇s ADR monitoring.