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Survivin多肽疫苗治疗血液系统恶性肿瘤的研究进展 被引量：2

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摘要 Survivin基因是近年来发现的凋亡抑制基因，它是凋亡抑制蛋白因子（Inhibitorsofapoptosisproteins，IAPs）家族的成员之一。人类基因转录的全球性研究揭示：在肿瘤细胞高度转录的基因中，Survivin位居第4。且因为其表达具有高度的肿瘤特异性，被认为是IAPs成员中在肿瘤领域最为瞩目的一个研究热点。
作者 罗颖 徐酉华
机构地区 重庆医科大学附属儿童医院血液科
出处 《重庆医科大学学报》 CAS CSCD 2007年第10期1118-1120,共3页 Journal of Chongqing Medical University
关键词 SURVIVIN基因 血液系统恶性肿瘤 疫苗治疗 凋亡抑制基因 多肽 基因转录 肿瘤特异性 蛋白因子
分类号 R735.2 [医药卫生—肿瘤]
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二级参考文献22

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共引文献11

同被引文献12

  • 1王家祥,郑树.Caspase-3 and survivin expression in pediatric neuroblastoma and their roles in apoptosis[J].Chinese Medical Journal,2004,17(12):1821-1824. 被引量：39
  • 2张俊,钱亚云,龚卫娟,胡茂志,季明春.利用流式细胞仪检测人外周血NK细胞毒性方法的建立[J].实用临床医药杂志,2006,10(4):28-31. 被引量：4
  • 3卢琳,李绪彤,张婷,杨金平,崔为发.γ-干扰素对白血病细胞Fas/FasL系统的调控及凋亡的影响[J].中国肿瘤生物治疗杂志,2006,13(4):277-280. 被引量：2
  • 4Ambrosini G, Adida C, Altieri D C. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma [J]. Nat Med,1997,3:917-921.
  • 5Tsuruma T,Iwayama Y, Ohmura T, Katsuramaki T, Hata F, Furuhata T, et al. Clinical and immunological evaluation of antiapoptosis protein, survivin-derived peptide vaccine in phase Ⅰ clinical study for patients with advanced or recurrent breast cancer[J]. J Transl Med, 2008,6 : 24.
  • 6Idenoue S, Hirohashi Y, Torigoe T, Sato Y, Tamura Y, Hariu H, et al. A potent immunogenic general cancer vaccine that targets survivin,an inhibitor of apoptosis proteins[J]. Clin Cancer Res, 2005,11: 1474-1482.
  • 7Otto K,Andersen M H,Eggert A,Keikavoussi P,Pedersen L Rath C,et al. Lack of toxicity of therapy induced T cell respon ses against the universal tumour antigen survivin[J]. Vaccine 2005,23 : 884-889.
  • 8Xiang R,Mizutani N,Luo Y,Chiodoni C,Zhou H,Mizutani M, et al. A DNA vaccine targeting survivin combines apoptosis with suppression of angiogenesis in lung tumor eradication[J]. Cancer Res,2005,65:553-561.
  • 9Kitamura H, Torigoe T, Honma I, Asanuma H, Nakazawa E, Shi mozawa K, et al. Expression and antigenicity of survivin, an inhibitor of apoptosis family member, in bladder cancer: implications for specific immunotherapy[J]. Urology, 2006,67 : 955-959.
  • 10王斌,刘磊,张丽辉.重组腺病毒载体介导共刺激分子B7.1基因对儿童肝母细胞瘤体外淋巴细胞增值的影响[J].中国优生与遗传杂志,2007,15(11):24-27. 被引量：1

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重庆医科大学学报
2007年 第10期

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