肿瘤微转移研究进展

Progress on the micrometastasis of tumor

随着外科技术和多种辅助治疗手段的不断进步，恶性肿瘤的疗效取得一定成绩，但总的预后仍然较差。由微转移形成的转移和复发是癌症致死的主要原因。应用免疫学和分子生物学方法检测骨髓、外周血和淋巴结的微转移可以提高临床分期、选择可行的治疗方案、监测辅助治疗的反应和寻找新的肿瘤靶向治疗策略。现就微转移的检测方法、临床标本的获取和肿瘤标志物的选择等方面的最新研究进展逐一论述。

Although the therapeutic effects of malignant tumor seem improved with the advance in surgical techniques and muhimodel adjurant therapy, the prognosis still remains poor. Metastasis and relapse from primary tumors are considered the lead cause of metastasis formation and relapse of cancer. Detection of micrometastasis in bone marrow, peripheral blood and lymphnole with immunological and molecularbiology methods may improve the clinical stage, select available therapeutic regimen, monitor response to adjuvant therapy and search novel targeted therapeutic strategy. This paper presents the lastest progress on the detection method, collection of sample and choice of tumor marker.