肝缺血再灌注损伤与肿瘤细胞的肝内捕获及生长

Relationship between hepatic ischemia reperfusion injury and trmor arrest and growth with the liver

肝缺血再灌注损伤（hepatic ischemia reperfusion injury，HIRI）是肝脏外科中常见的病理生理过程，是术后肝衰竭或原发性移植物无功能的重要原因。HIRI引起的黏附分子表达升高、中性粒细胞浸润、局部微循环紊乱、肝窦内皮肿胀、大量缩血管因子释放以及后期肝实质坏死、组织结构破坏及局部低氧环境可促进循环中肿瘤细胞的肝内捕获及浸润生长，本文就近年来相关研究作一综述。

Hepatic ischemia reperfusion injury （HIRI） is a commom pathophysiologyical process, which is the prime cause contributing to the liver failure or primary nonfunctional graft in post-operation. HIRI promotes the arrest of circulating homologous tumor cells and the growth of the pre-existing intrahepatic ones through the following aspects, such as high-expressed eell adhesion molecules, swelling endothelial cells, local imbalance in vasoconstrictors and vasodilators, activation of the coagulation system, the influx of neutrophils, destruction of the liver parenchyma and local hypoxia result from ＂no-reflow＂.