细胞周期抑制蛋白p16、p27蛋白表达与垂体腺瘤侵袭性的关系

Expressions of cell cycle-related proteins p16,p27 and invasive in pituitary adenoma

目的探讨p27、p16、PCNA的蛋白表达与垂体腺瘤侵袭性的关系,为根治垂体腺瘤及减少肿瘤术后复发提供实验依据。方法应用免疫组化SP法检测43例侵袭性垂体腺瘤和37例非侵袭性腺瘤的p16、p27和PCNA蛋白表达水平,分析p16、p27蛋白表达水平与PCNA蛋白表达之间的相关性。结果垂体侵袭腺瘤p16、p27蛋白表达较非侵袭组明显减低;复发组p16蛋白表达的阳性率与非复发组之间无统计学意义。p27蛋白表达的阳性率较非复发组减低有显著差异。结论p16、p27蛋白表达异常与垂体腺瘤的发生及侵袭性有关,它们的表达情况能作为垂体腺瘤侵袭性的参考指标。

Objective To study the relationship between the protein expressions of PCNA,p16, p27 and invasive in pituitary adenoma,to offer the experiment basis on effecting radical cure of pituitary adenomas and decreasing the recurring after surgery.Methods The expressions of protein were examined by immunohistochemical SP methods in 43 invasive pituitary adenomas and 37 non-invasive adenomas.To analyze the correlation of the abnormal expression of proteins p16,p27 and the proliferation cell nuclear antigen （PCNA） in pituitary adenomas.Results The expression of protein p16,p27 in invasive pituitary adenomas group were significantly lower than non-invasive group.There was no significant difference of the expression of protein p16 in recurring and non-recurring groups.The expression of protein p27 in recurring pituitary adenomas group were significantly lower than non-recurring group.Conclusions The abnormal protein expression of p16 and p27 may play roles in tumorigenesis and progression of pituitary adenoma,which can be taken as indicators to evaluae the tumor invasive potential and prognosis.