聚乳酸/羟基磷灰石复合骨修复材料的改性及应用特征

Modification and application characteristics of polylactide/hydroxyapatite composite as bone repairing material

目的:总结国内外对聚乳酸/羟基磷灰石复合材料的性能、改性和应用的研究现状。资料来源:应用计算机检索Medline,Elsevier Science和CNKI数据库1998-01/2007-05期间与聚乳酸/羟基磷灰石复合材料相关文章,中文检索词:"羟基磷灰石,聚乳酸/羟基磷灰石"等;英文检索词:"hydroxyapatite,polylactide/hydroxyapatite"。资料选择:对资料进行初选,选择聚乳酸/羟基磷灰石复合材料的制备、性能、改性和应用方面的文献。纳入标准:①羟基磷灰石性能及影响性能的因素。②羟基磷灰石改性研究。③PLA/HA的应用。资料提炼:粗选有几百篇关于聚乳酸/羟基磷灰石复合材料的文章,根据纳入标准,精选66篇文献,排除重复性文献,最后纳入32篇文献进行综述。资料综合:聚乳酸/羟基磷灰石复合材料是骨修复材料的典型代表,具有良好的生物相容性,羟基磷灰石已经做了大量的改性研究,提高了复合材料的力学性能和热稳定性。聚乳酸/羟基磷灰石复合材料在生物医学领域的应用主要包括以下3个方面:①骨科固定材料。②组织工程支架材料。③临床上已被广泛应用于组织工程中骨和软骨组织的构建和再生。结论:聚乳酸/羟基磷灰石复合材料已在生物医学领域得到广泛应用,是一种很有发展潜力的骨修复材料。

OBJECTIVE： To summarize the research status of property, modification and application of polylactide （PLA） /hydroxyapatite （HA） in domestic and overseas. DATA SOURCES： A computer-based online search of Medline, Elsevier Science and CNKI database was untaken for literature about PLA/HA published between January 1998 and May 2007 with the keywords of ＂hydroxyapatite or ＂ in English and Chinese, respectively. STUDY SELECTION： After the first trial, literatures about preparation, property, modification and application of PLA/HA; the property and impacted factors of HNPLA; modified study on PLA/HA; and applied research on PLA/HA were selected. DATA EXTRACTION： Hundreds of papers about PLA/HA were collected, and 66 were in accordance with the inclusive criteria. The repetitive articles were eliminated. Finally, 32 articles were analyzed. DATA SYNTHESIS： PLA/HA copolymer is the representative material of bone repairing with good biocompatibility, Many studies on the modification of HA have been carried on to improve its strength property and thermal stability. PLA/HA is mainly used as ①fixation material in orthopedics, ②scaffold material in tissue engineering, and ③ used in the construction and regeneration of bone and cartilage in tissue engineering. CONCLUSION： PLA/HA has been applied in biological medical fields widely. It is a kind of bone repairing material with developing potential.