人工晶状体表面修饰技术研究

Study on surface modification of intraocular lens

目的通过表面修饰技术对硅凝胶人工晶状体进行表面改性,以提高修饰后人工晶状体的生物相容性,开拓新型人工晶状体。方法采用低温等离子体联合离子束技术对硅凝胶人工晶状体进行钛及钛基复合材料的表面改性。观察修饰后人工晶状体的分辨率以及扫描电镜下人工晶状体表面形态的变化。结果钛修饰的人工晶状体呈现微黄色;氮化钛修饰的人工晶状体为微棕色。未修饰与修饰人工晶状体的分辨率均符合标准;未修饰与钛修饰人工晶状体的表面呈均质状,氮化钛修饰人工晶状体表面可见钧瓷样细密的纹理结构。结论表面修饰技术不影响人工晶状体本体的光学性质及表面形态,低温等离子体联合离子束技术是一种医用生物材料表面改性的有效的新方法。

Objective To develop a new kind of biocompatible intraocular lenses（IOLs）. Methods Silicone IOLs were modified with titanium and titanium nitride by the technique of ion beam combined with low temperature and low pressure plasma. The IOLs resolution and surface morphology were observed by scanning electron microscope. Results Ti-modified IOLs showed the light yellow color,and TiN-modified IOLs showed pale brown color. The resolution of unmodified and modified IOLs reached normal standard. The surfaces of unmodified and Ti-modified IOLs appeared uniform, and the surfaces of TiN modified IOLs presented fine porcelain structure under the scanning electron microscope. Conclusion Optical properties and surface morphology of the modified IOLs are altered by modification processes. The technique of ion beam combined with low temperature and low pressure plasma is an effective and new method on surface modification of the biomedical materials.