2-硝基苯基苯并咪唑衍生物微波合成

Microwave synthesis of 2-nitrophenzyl-benzimidazole derivatives

在微波辐射下,以乙醇为溶剂,以邻苯二胺和硝基苯甲醛为原料,合成3种2-硝基苯基苯并咪唑.利用正交法优化微波促进该反应工艺条件,优化工艺参数为n(邻苯二胺)∶n(硝基苯甲醛)=1.2∶1.0,微波辐射温度为58℃,微波辐射20min.在优化条件下产率达81.2%,产物经熔点测试,采用IR和1HNMR进行表征确认.

2-nitrophenzyl-benzimidazole was synthesized by the reaction of o-phenylenediamine with nitro-benaldehyde which was accelerated by microwave irradiation and ethyl alcohol as solvent. The method of orthogonal experiment was used to optimize synthesis factors which affect the reaction： n （o-phenylenediamine） ： n （nitro benalde- hyde） = 1.2： 1.0, and the temperature of microwave irradiation 58℃, the time of microwave irradiation 20 min. Under the optimal condition, the highest yield of the title compound was a bout 81.2%. The samples synthesized were characterized by melting point determination, IR spectrogram,^1HNMR spectra.