摘要
在微波辐射下,以乙醇为溶剂,以邻苯二胺和硝基苯甲醛为原料,合成3种2-硝基苯基苯并咪唑.利用正交法优化微波促进该反应工艺条件,优化工艺参数为n(邻苯二胺)∶n(硝基苯甲醛)=1.2∶1.0,微波辐射温度为58℃,微波辐射20min.在优化条件下产率达81.2%,产物经熔点测试,采用IR和1HNMR进行表征确认.
2-nitrophenzyl-benzimidazole was synthesized by the reaction of o-phenylenediamine with nitro-benaldehyde which was accelerated by microwave irradiation and ethyl alcohol as solvent. The method of orthogonal experiment was used to optimize synthesis factors which affect the reaction: n (o-phenylenediamine) : n (nitro benalde- hyde) = 1.2: 1.0, and the temperature of microwave irradiation 58℃, the time of microwave irradiation 20 min. Under the optimal condition, the highest yield of the title compound was a bout 81.2%. The samples synthesized were characterized by melting point determination, IR spectrogram,^1HNMR spectra.
出处
《深圳大学学报(理工版)》
EI
CAS
北大核心
2007年第3期309-312,共4页
Journal of Shenzhen University(Science and Engineering)
关键词
微波合成
苯并咪唑衍生物
正交实验
有机合成
microwave irradiation
benzimidazole derivatives
orthogonal experiment
organic synthesis