摘要
目的:阐明富于细胞性血管纤维瘤的临床病理形态特征及鉴别诊断。方法:报道1例腹股沟富于细胞性血管纤维瘤并进行组织形态学、免疫组织化学研究。结合文献分析本病的临床表现、病理形态特点及鉴别诊断。结果:富于细胞性血管纤维瘤呈不规则小叶状,瘤细胞呈短梭形、大小一致、核卵圆至梭形、核分裂象不易见。肿瘤含大量的小至中等大小的血管,以无分支的毛细血管为主,血管壁增厚,玻璃样变,黏液样基质丰富。免疫组化:肿瘤细胞Vimentin阳性,而CD34、S-100、desmin、CK、EMA、Ki-67、CD44及HMB45均阴性。结论:富于细胞性血管纤维瘤是一种极少见的特殊的外阴部良性软组织肿瘤,肿瘤可能存在间质细胞增生活性不同的组织学亚型。
Objective:To investigate the pathornorphologic features and diferential diagnosis of cellular angiofr-broma(CA) . Methods:A case of CA(a 36 years-old man) was studied with histopathologic observation and immunohis- tochemical staining. Its differential diagnosis from other soft tissue tumors in the vulva was discussed. Results:Micro-scopically,the tumor was characterized by an irregular lobular growth pattern,uniform and short spindled stromal cells with avoid to fusiform nuclei numerous small to medium sized blood vessels with thick-walled and pronounced hyaliniza-tion. Mitotic figure was absent. The matrix of the tumor showed extensive myxoid appearance Immunohistochemically, the tumor cells were positive for vimentin, but negative for CD34, S-100 protein,desmin,CK, Ki-67,CD44 and HMB45. Conclusion:CA is a rare distinctive benign soft tissue tumor in the vulva. The tumor has different variants with various proliferative activity of the stromal cells.
出处
《中国误诊学杂志》
CAS
2007年第17期3955-3957,共3页
Chinese Journal of Misdiagnostics