1Wettschureck N,Offermanns S.Rho/Rho-kinase mediated signaling in physiology and pathophysiology[J].J Mol Med,2002,80(10):629-638.
2DerMardirossian C,Bokoch GM.GDIs:central regulatory molecules in Rho GTPase activation[J].Trends Cell,2005,15(7):356-363.
3Fujisawa K,Madaule P,Ishizaki T,et al.Different regions of Rho determine Rho-selective binding of different classes of Rho target molecules[J].J Biol Chem,1998,273(30):18943-18949.
4Piuitt K,Der CJ.Ras and Rho regulation of the cell cycle and oncogenesis[J].Cancer Lett,2001,71(1):1-10.
5Sah VP,Seashdtz TM,Sagil SA,et al.The role of Rho in G proteincouple receptr signal transduction[J].Annu Rev Pharmacol Toxicol,2000,40:459-489.
6Fukata M,Kaibuchi K.Rho family GTPases in cadherin-mediated cell-cell adhesion[J].Nat Rev Mol Cell Biol,2001,2(12):887-897.
7Sahai E,Olson MF,Marshall CJ.Cross-talk between Ras and Rho sig nalling pathways in transformation favours proliferation and increased motility[J].EMBO J,2001,20(4):755-766.
8Aznar S,Valeron PF,Rincon SV,et al.Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in rhoa GTPase oncogenic transformation[J].Mol Biol Cell,2001,12(10):3282-3294.
9Pille JY,Denoyelle C,Varet J,et al.Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo[J].Mol Ther,2005,11(2):267-274.
10Kamai T,Arai K,Sumi S,et al.The rho/rho kinase pathway is involved in the progression of testiculargerm cell tumour[J].BJU Int,2002,89(4):449-453.
2Sahai E, Marshall CJ. Rho-GTPases and cancer. Nat Rev Cancer,2002 .2: 133-142.
3Tapon N, Hall A. Rho, Rac and cdc42 GTPases regulate the organization of the actin cytoskeleton. Curr Opir Cell Biol, 1997, 9:86-92.
4Kranenburg O, Poland M, Gebbink M, et al. Dissociation of LPAinduced cytoskeletal contraction from stress fiber formation by differential localization of RhoA..I Cell Sci , 1997 , 110:2417-2427.
5Koch G, Benz C, Schmidt G, et al. Role of Rho protein in lovastatin-induced breakdown of actin cytoskeleton. J Pharmacol Exp Ther, 1997,283 : 901-909.
6Qiu RG, Chen J, McCormick F, et al. A role for Rho in Ras transformation. Proc Natl Acad Sci USA, 1995, 92: 11781-11785.
7Liberto M, Cobrinik D, Minden A. Rho regulates p21 ( CIP1 ) cyclin D1, and checkpoint control in mammary epithelial cells. Oneogene ,2002, 21 : 1590-1599.
8Vidal A, Millard SS, Miller JP, et al. Rho activity can alter the translation of p27 mRNA and is important for RasV12-induced transformation in a manner dependent on p27 status. J Biol Chem, 2002,277 : 16433-16440.
9Seasholtz TM, Zhang T, Morissette MR, et al. Increased expression and activity of RhoA are associated with increased DNA synthesis and reducedp27(Kipl) expression in the vasculature of hypertensive rats. Circ Res,.2001, 89: 488-495.
10Fritz G, Just I, Kaina R. Rho GTPases are overexpressed in human tumors. Int J Cancer, 1999, 81:682-687.