原癌基因c—Met在子宫内膜癌中表达的研究

Expressions of c - Met in endometrial carcinoma

目的 研究原癌基因c—Met在子宫内膜癌中的表达及其意义。方法 采用免疫组织化学SP的方法，研究50例子宫内膜癌组织及20例正常子宫内膜组织中原癌基因c—Met的表达。结果 子宫内膜癌中c—Met阳性表达率高于正常子宫内膜（P〈0．05），且与组织分级、肌层浸润深度、临床分期显著相关（P〈0．05）。结论c—Met的过表达在子宫内膜癌变中起重要作用，促进了子宫内膜癌的发生和发展，对判断子宫内膜癌的恶性程度有较重要价值。

Objective To investigate the expression of proto -oncogene c -Met in endometrial carcinoma. Methods A to- tal of 45 specimens of endometrial carcinoma were evaluated by immunohistochemical techique with polyclonal antibody against c - Met. Results The positive expression rate of c - Met was significantly higher in EC than in normal endometrium （ P 〈 0. 05）. The expression level of c - Met was significantly correlated with grade, mymometrial invasion and stage （ P 〈 0.05 ）. Conclusion c - Met plays an important role in tumorigenesis and in judging the malignancy of endometrial carcinoma.