急性心肌梗塞患者血浆内皮素水平变化的意义

Significance of Changes of Plasma Endothlin Levels in the Patiens with Acute Myocardial Infarction

动态观察28例急性心肌梗塞(AMI)患者血浆内皮素(ET)及血清肌红蛋白(Mb)水平的变化,并同时选择13倒不稳定心绞痛(UA)患者和15例健康人做为对照。结果表明,AMI组血中ET及Mb水平均于梗塞24小时之内达峰值,且随病程延长而逐渐下降,7天后降至正常范围,AMI组血浆ET水平显著高于UA组及正常组(P<0.01),其中UA组又明显高于正常组(P<0.01);相关分析显示AMI患者血浆ET水平与血清Mb水平呈正相关(r=0.5832,P<0.01)。提示血浆ET水平测定可做为监测AMI临床过程及估测心肌损害程度的一项指标。

The levels of plasma endothelin (ET) and serum myoglobin (Mb)of 28 patients with acute myocardial infarction (AMI) were monitored, meantime 13 unstable angina (UA) pa-tients and 15 healthy people (normal group) were selected as the controls. The results showed: the peak of circulating ET and Mb arrived within 24 hours after AMI, the levels of ET and Mb fell gradually and restored to normal one 7 days after AMI. The levels of plasma ET in group AMI were higher markedly than that of group UA and normal group (P<0. 01), and the levels of plas-ma ET of group UA were higher than normal group (P<0. 01). Correlative analysis between in-crease of plasma ET and serum Mb in group AMI was positive (r=0. 5832,P<0. 01). The above results prompted that detemine of plasma ET levels in AMI could act as a parameter to monitor the clinical course and estimate the degree of myocardium injury.