米非司酮抗早孕后出血量与宫腔组织学观察

The Blood Loss and Endometrial Histological Changes Following Termination of Early Pregnancy Using Mifepristone

本文采用碱性正铁血红素比色法定量测定40例妇女口服米非司酮配伍米索前列醇抗早孕后的子宫出血量，并对胚囊排出后一周时的子宫内膜组织学进行了观察分析。结果表明，药物流产后一周内阴道流血量平均为132．15±100．73ml，在胚囊脱落当日出血量较多。妊娠终止一周时宫腔组织物中65．0％含蜕膜组织，仅已5.0％含游离个别绒毛。子宫内膜呈增生与分泌共存现象或分泌现象分别占35．0％、20．0％。由此可见，蜕膜组织排出缓慢和子宫内膜的修复障碍可能是米非司酮终止早孕后阴道出血量多，流血时间长的主要原因。

The volume of blood loss following the termination of early pregnancy after oral administra-tion of inifeprostone and misoprostol was determined in 40 patients by alkaline hematin photomet-ric method,and endometrial histological changes one week after the expulsion of embryo was ob-served and analyzed- Results showed that the average blood loss for one week after abortion was132. 15±100.73ml,the most blood loss was on the day of expulsion. In the samples obtained bythe end of one week after termiantion of pregnancy,decidua was found in 65.0% of cases,and inonly 5.0% could a few of isolated villi be detected' Proliferative endornetria with secretorychanges were found in 35.0% of endometrial specimen,and only secretory changes in 20.0%. Re-sults suggested that the profuse and/or prolonged bleeding may be due to slow separation and de-layed repairrnent of endometrium.