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米非司酮配伍前列腺素抗早孕的临床试验 被引量:17

A Clinical Trial on the Termination of Early Pregnancy Using Chinese-made Mifepristone Combined with Prostaglandin
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摘要 上海市15个单位合作完成米非司酮配伍前列腺素抗早孕,按常规筛选对象共1884例。米非司酮分次给药共150mg,第3天随机给于PG05栓1mg置后穹窿或米索前列醇0.6mg顿服。结果完全流产率95.1%。效果与不同产地的米非司酮和不同前列腺素无差异;与以往人流或自然流产史、体重、胚囊直径、孕妇血色素、有无恶心呕吐等有关。药流副反应轻。完全流产后平均出血时间14.91±7.66d。药流后的对象满意度达85%以上。说明本法抗早孕安全有效、反应轻,建议通过培训、掌握常规,在有抢救条件的基层医疗单位推广应用。 One thousand eight hundred and eighty four cases of early pregnancy were terrninated bymifepristone combined with prostaglandin in 13 hospitals,Shanghai. The subjects were selected byroutine. The total dose of 150 mg of mifepristone was divided to 5 times in 3 days,and 1 mg sup-porsitory of PG05 or 0. 6 mg misoprosol was given on the third day. The complete abortion ratewas 95. 1%. The efficacies were of no statistical difference among the mifepristone products ofdifferent area or PGs, but may be related with the histories of induced or spontaneous abortion,body weight,diameter of embryonic sac,hemoglobin level and nausea or vomiting etc. The side effects were quite low. The average duration of bleeding in the case of complete abortion was 14. 91±7. 66 days. 85% subjects c0nsidered satisfactory after treatment. The study showed thatmifepristone combined.with PGs to terminate early pregnancy is a safe,effective method with lowside effects,and suggested it can be popularized by trained medical personal.
机构地区 上海地区协作组
出处 《生殖与避孕》 CAS CSCD 北大核心 1997年第2期86-91,共6页 Reproduction and Contraception
关键词 米非司酮 前列腺素 抗早孕 Mifepristone, Prostaglandin, Termination of early pregnancy
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  • 1杜明昆,卢玉兰,吴学浙,李红,金毓翠.卡前列素栓配伍米非司酮终止早孕的临床多中心比较性研究[J].生殖与避孕,1993,13(6):436-441. 被引量:12
  • 2杜明昆,中国计划生育学杂志,1992年,2卷,27页
  • 3桑国卫,中国计划生育学杂志,1992年,2卷,10页
  • 4贺昌海,中国计划生育学杂志,1993年,2卷,19页
  • 5杜明昆,中国计划生育学杂志,1992年,2卷,27页
  • 6翁梨驹,北京医学,1988年,10卷,135页
  • 7朱筱玲,北京医学,1988年,10卷,279页

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