糖尿病鼠肾脏肾素血管紧张素系统活性的改变

SERIAL OBSERVATIONS ON RENIN ANGIOTENSIN SYSTEM ACTIVITY IN STZ INDUCED DIABETIC RATS

研究３７只病程１～６个月糖尿病及２９只同龄对照大鼠血浆及肾组织肾素活性、ＡＴⅡ含量、肾组织血管紧张素原基因ｍＲＮＡ表达水平等改变。发现仅在病程３个月时糖尿病鼠血浆ＡＴⅡ及肾组织血管紧张素原ｍＲＮＡ表达水平升高，病程１～６个月糖尿病鼠肾组织ＡＴⅡ含量均升高。结果显示：糖尿病鼠肾组织与血浆肾素血管紧张素系统活性改变呈不平行现象；肾组织肾素－血管紧张素系统活性增强可能是糖尿病肾病形成及发展的重要因素之一。

lasma and renal tissue renin activities(PRA, TRA), angiotensinⅡ(ATⅡ) and renal tissue angiotensinogen mRNA expression levels were assessed in 37 STZ induced diabetic rat with 1,3,6 month duration of diabetes (DM1, DM2,DM3) and 27 age matched nornal control rat (C1, C2,C3). The result showed that PRA and TRA were not significantly different between all diabetic and their control groups. Increased plasma ATⅡ concentration and renal angotensinogen mRNA expression levels were found higher in DM2 than those in C2. However, renal tissue angiotensin concentrations were higher in all DM groups than those in C groups. The result indicated the activity of plasma and renal tissue renin angiotensin system did not always in parallel and the increased activity of renal tissue renin angiotensin system might be one of important factors in the initiation and progression of diabetic nephropathy.