摘要
研究37只病程1~6个月糖尿病及29只同龄对照大鼠血浆及肾组织肾素活性、ATⅡ含量、肾组织血管紧张素原基因mRNA表达水平等改变。发现仅在病程3个月时糖尿病鼠血浆ATⅡ及肾组织血管紧张素原mRNA表达水平升高,病程1~6个月糖尿病鼠肾组织ATⅡ含量均升高。结果显示:糖尿病鼠肾组织与血浆肾素血管紧张素系统活性改变呈不平行现象;肾组织肾素-血管紧张素系统活性增强可能是糖尿病肾病形成及发展的重要因素之一。
lasma and renal tissue renin activities(PRA, TRA), angiotensinⅡ(ATⅡ) and renal tissue angiotensinogen mRNA expression levels were assessed in 37 STZ induced diabetic rat with 1,3,6 month duration of diabetes (DM1, DM2,DM3) and 27 age matched nornal control rat (C1, C2,C3). The result showed that PRA and TRA were not significantly different between all diabetic and their control groups. Increased plasma ATⅡ concentration and renal angotensinogen mRNA expression levels were found higher in DM2 than those in C2. However, renal tissue angiotensin concentrations were higher in all DM groups than those in C groups. The result indicated the activity of plasma and renal tissue renin angiotensin system did not always in parallel and the increased activity of renal tissue renin angiotensin system might be one of important factors in the initiation and progression of diabetic nephropathy.
出处
《中山医科大学学报》
CSCD
1997年第2期104-106,136,共4页
Academic Journal of Sun Yat-sen University of Medical Sciences
基金
国家教委博士点基金
关键词
糖尿病
肾病
并发症
肾素
血管紧张素系统
mRNA
diabetes mellitus, experimental/complications
diabetic nephropathies/complications
renin angiotensin system
RNA, messenger