胃癌高发区和低发区幽门螺杆菌感染血清学调查

A COMPARISON OF THE PREVALENCE OF Helicobacter pylori INFECTION IN AREAS OF HIGH AND LOW MORTALITY OF GASTRIC CANCER

用血清学方法对胃癌高发区兰州地区３７８１名各年龄组健康人群进行前瞻性幽门螺杆菌（Ｈｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉ，ＨＰ）感染调查，并与胃癌低发区广州地区的资料进行比较。结果显示：兰州地区ＨＰ总感染标化率为６１．６％，高于广州地区的４８．３％（Ｐ＜０．００１）。两者之间的差异在１０岁以下儿童，尤其是４岁以下幼儿最显著（分别为４３．２％与１９．３％，Ｐ＜０．００１）；兰州地区ＨＰ阳性率的高峰年龄段在３０～３９岁，比广州地区提早１０年以上出现，可能与胃癌高发区人群较早出现ＨＰ相关性萎缩性胃炎及肠上皮化生有关。

The prevalence of Helicobacter pylori(HP) infection in Lanzhou, an area of high gastric cancer mortality, was compared with the data obtained previously in Guangzhou, an area of low gastric cancer mortality. The sera were taken from 3781 healthy persons in 1274 from Lanzhou urban area and 2507 from suburban counties. Anti HP IgG was tested using ELISA method. The results showed that the overall HP standardized positive rate in Lanzhou area was 60.3%, which was significantly higher than 48.3% in Guangzhou area (P<0.001). Comparison of the age distribution of HP infection in the two areas revealed that the rate of HP infection in children of Lanzhou area was much higher than that in Guanghzou area, especially in those below 4 years old (43.2% vs. 19.3%, P<0 001). The peak age of HP infection in Lanzhou area was in 30～39 age group, i.e. 10 years younger than Guangzhou area. The results supported the hypothesis that early HP infection in young children contributed to the development of gastric cancer. Further investigation of multiple factors are strongly indicated.