腹腔热化疗并微波局部热疗对癌症患者腹水VEGF的影响观察

Observation of malignant abdominal cavity dropsy VEGF with infusion hyperthemic chemathrapy and thermoradiothrapy

目的：研究腹腔热化疗并微波局部热疗对恶性肿瘤患者腹水VEGF表达的影响,以及治疗后腹水VEGF的变化与疗效的关系。方法：56例确诊为癌性腹水患者随机分为腹腔热化疗组（腹水引流后,顺铂40-60mg/次,直接加入50℃生理盐水600 ml内,注入腹腔,每周2次,连用2周休息1周,3周为1个周期）28例,热化疗并微波局部热疗组（热化疗后1.5h内,射频热疗仪腹腔局部热疗,每次60-120min,皮肤温度控制在41-43℃之间）28例,于治疗前、治疗后及治疗后4周分别测腹水VEGF值并观察腹水疗效。结果：两组患者治疗后VEGF值均与治疗前有显著差异（P〈0.01）,但对照组治疗后4周VEGF值恢复到治疗前水平（P〉0.05）,而治疗组4周后仍有显著差异（P〈0.01）。结论：热化疗并局部热疗对恶性腹水治疗效果较好,对腹水中VEGF表达影响显著,腹水中VEGF值的监测可作为疗效及预后指标。

Objective：To study the influence of malignant abdominal cavity dropsy VEGF with infusion hyperthemic chemotherapy and thermoradiothrapy. Methods ：56 patients with malignant abdominal dropsy were randomly divided into two groups： 28 patients were treated by DDP 40-60mg,which was resolved in 600ml distilled water at 50℃, twice weekly,the third week was rest,while the other patients plus thermoradiotherapy for 60- 120min every day, which was used after hyperthemic chematherapy 1.5 h, twice weekly also. Before therapy, 6 weeks and 10 weeks the abdominal cavity dropsy VEGF were compared. Results：All patients, the difference of before therapy and 6 weeks was significant （P〈 0. 01）, but the VEGF level of control group recovered sooner. Conclusions： Hyperthermic chemotherapy and themoradiothrapy are all efficient to malignant abdominal dropsy ,VEGF level would drop following the effective and it can be regarded as rule of effects and prognosis.