骨髓活检组织病理学检查的临床应用价值

Clinic value of bone marrow histopathology

目的:对9760例/次骨髓活检组织病理变化及骨髓涂片检查进行对照分析,旨在评价骨髓活检在临床应用中的价值。方法:一步法取骨髓涂片和骨髓活检组织行塑料或石蜡包埋切片,做HGF、MGG、Comori和Masson三色各染色一张切片,骨髓涂片行瑞氏染色。结果:塑料包埋效果优于石蜡包埋,活检切片判断骨髓增生度明显优于涂片,对再障、骨纤、骨髓转移癌、骨髓增生性疾病、骨髓增生异常综合征、淋巴瘤等疾病的诊断阳性率明显高于骨髓涂片(P<0.01)。结论:骨髓活检并不能代替涂片形态检查,只有活检与涂片二重检查密切配合分析,才能提高诊断率及评估疗效和预后。

Objective： To evaluate the clinic value of bone marrow histopathology, we cooperated bone marrow histopathology to bone marrow smears in 9760 patients. Methods：The patients＇ bone marrow with bone marrow metastatic cancers were aspirated in one step. Paraffin or plastics pack cover up marrow organization,HGF or MGG, Gomori and Masson dye a slice; Wright dye morrow slice. Results： The results showed that pack cover up marrow organization the bone marrow biopsy was obviously more superior than paraffin one. Bone marrow biopsy was obviously more superior than bone marrow smears in evaluating the degree of myeloidosis and in increasing the correct rate of diagnosis as to aplastic anemia, bone marrow fiberosis, bone marrow metastatic cancers ,myeloproliferative diseases ,myelodys plastic syndrom and lymphoma（P〈0.01）. Conclusion： Bone marrow biopsy do not replace bone marrow smears. Uniting bone marrow histopathology with bone marrow smears can improve the rate of diagnosis and assess the medical treatment and the prediction.