口服重组GAD65蛋白延缓NOD小鼠Ⅰ型糖尿病发生

Oral use of GAD65 porotein delays the onset of type Ⅰ diabetes mellitus in nonobese diabetic mice

目的研究重组GAD65蛋白对NOD小鼠1型糖尿病的预防作用。方法6周龄NOD雌鼠1周3次灌胃重组GAD65蛋白,共32周,观测胰岛炎和糖尿病发病。结果重组GAD65蛋白能明显降低NOD小鼠糖尿病的发生和胰岛炎的严重程度。结论口服重组GAD65蛋白能预防NOD鼠糖尿病。

Objective To explore the effect of GAD65 protein on delaying the onset of type Ⅰ diabetes in NOD mice. Methods Female NOD mice, 6 weeks old, were administered with GAD65 protein three times a week via gavage for 6 to 56 weeks. Results Administering GAD65 protein to female NOD mice could significantly suppress their diabetes and insulitis. Conclusion Oral use of GAD65 protein can prevent the NOD mice from suffering diabetes.