大鼠重度创伤后血浆内皮素与降钙素基因相关肽水平的变化

Changes of plasma endothelin and calcitonin-gene related peptide after traumatic shock in rats

目的:探讨重度创伤性休克对大鼠血浆内皮素(ET)、降钙素基因相关肽(CGRP)水平及动脉血气分析的影响。方法:采用后肢创伤法建立创伤性休克大鼠模型,测定创伤前后及复苏后1、3、5、12 h血浆ET、CGRP及动脉血气分析水平。结果:在休克末及复苏后1、3、5、12 h,大鼠血浆ET、CGRP水平及动脉血二氧化碳分压(PCO2)、氧分压(PO2)及氧饱和度(SO2)发生明显变化。血浆ET和CGRP含量与休克前相比较明显的升高,峰值出现在复苏后5 h,同时伴有PCO2升高,而PO2和SO2明显下降。结论:创伤性休克血浆ET、CGRP水平明显升高且伴随着PCO2,PO2和SO2的变化。ET和CGRP在创伤性休克中起着重要的作用。

Objective：To observe the effects of traumatic shock on the plasma endothelin （ET）, calcitonin - gene related peptide （CGRP） and arterial blood gas analysis （ABGA） in rats. Methods： The rats were shocked by fracturing the posterior limbs. The plasma concentration of ET, CGRP and arterial blood gas analysis were measured before shock and after 1, 3, 5 and 12 h of resuscitation. Results： The level of ET, CGRP, PCO2, PO2 and SO2 in blood samples changed significantly at the end of shock and after 1, 3, 5 and 12h of resuscitation. The ET and CGRP level increased significantly compared with that before shock. The summit occurred 5 h after resuscitation. PCO2 in ABGA increased significantly, while PO2 and SO2 declined. Conclusion： The traumatic shock causes the change of ET, CGRP and ABGA in rats. ET and CGRP play an important role in traumatic shock resuscitation.