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自身抗体与先天性心脏传导阻滞 被引量：1

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摘要 新生儿红斑狼疮可发生于母体Ro／SSA和La／SSB抗体阳性的胎儿。母体尽管常被诊断为干燥综合征或者系统性红斑狼疮，但常常是无症状的。在妊娠期母体的自身抗体可通过胎盘输送给胎儿并使其产生病理性改变。新生儿狼疮综合征可表现为皮肤、肝脏和造血系统等多方面症状，这些症状都是暂时的，胎儿血液中自身抗体被清除后症状可消失，但是可能会产生先天性心脏传导阻滞的后遗症。
作者 胡良皞 秦永文
机构地区 第二军医大学附属长海医院心内科
出处 《中国心血管病研究》 CAS 2007年第8期631-634,共4页 Chinese Journal of Cardiovascular Research
关键词 心脏传导阻滞 自身抗体 先天性 新生儿红斑狼疮 系统性红斑狼疮 RO/SSA 胎儿血液 干燥综合征
分类号 R541.76 [医药卫生—心血管疾病]
  • 相关文献

参考文献35

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同被引文献23

  • 1Askanase AD, Friedman DM, Copel J, et al. Spectrum and progression of conduction abnormalities in infants born to mothers with anti-SSA/Ro-SSB/La antibodies [ J]. Lupus, 2002, 11:145-151.
  • 2Guettrot-Imbert G, Cohen L, Fermont L, et al. A newpresentation of neonatal lupus: 5 cases of isolated mild endocardial fibroelastosis associated with maternal Anti- SSA/Ro and Anti-SSB/La antibodies [J]. J Rheumatol, 2011, 38:378-386.
  • 3Liu J, Zhao Y, Song Y, et al. Pregnancy in women with systemic lupus erythematosus: a retrospective study of 111 pregnancies in Chinese women [ J]. J Matern Fetal Neonatal Med, 2012, 25:261-266.
  • 4Rozenblyum EV, Sukhdeo S, Jaeggi E, et al. A42 : anti-ro and anti-la antibodies in the general pregnant population: rates and fetal outcomes [ J ]. Arthritis Rheumatol, 2014, 66 Suppl 11 :$63.
  • 5Salomonsson S, Sonesson SE, Ottosson L, et al. Ro/ SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block [J]. J Exp Med, 2005, 201:11-17.
  • 6Clancy RM, Neufing PJ, Zheng P, et al. Impaired clearance of apoptotic cardiocytes is linked to anti-SSA/ Ro and-SSB/La antibodies in the pathogenesis of congenital heart block [J]. J Clin Invest, 2006, 116: 2413-2422.
  • 7Briassouli P, Halushka MK, Reed JH, et al. A central role of plasmin in cardiac injury initiated by fetal exposure to maternal anti-Ro autoantibodies [ J ]. Rheumatology ( Oxford), 2013, 52 : 1448-1453.
  • 8Alvarez D, Briassouli P, Clancy RM, et al. A novel role of endothelin-1 in linking Toll-like receptor 7- mediated inflammation to fibrosis in congenital heart block [J]. J Biol Chem, 2011, 286:30444-30454.
  • 9Ambrosi A, Salomonsson S, Eliasson H, et al. Development of heart block in children of SSA/SSB- autoantibody-positive women is associated with maternal age and displays a season-of-birth pattern [ J ]. Ann Rheum Dis, 2012, 71:334-340.
  • 10Clancy RM, Marion MC, Kaufman KM, et al. Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus [J]. Arthritis Rheum, 2010, 62: 3415-3424.

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中国心血管病研究
2007年 第8期

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