新生儿黄疸与窒息缺氧的关系探讨

目的探讨窒息缺氧与新生儿黄疸的关系。方法测定106例足月新生儿的血清胆红素值，并按轻度窒息缺氧组、重度窒息缺氧组和无窒息缺氧组分组进行比较。结果高胆红素血症发生率3组分别为28．6％、14．7％、46．7％，有显著性差异（P〈0．05），其中重度窒息缺氧组明显低于无窒息缺氧组（P〈0．01）；血清胆红素3组分别为（184．7±48．3）μmol／L、（153．2±48．9）μmol／L、（209．6±49．7）μmol/L，轻度窒息缺氧组低于无窒息缺氧组（P〈0．05），重度窒息缺氧组明显低于轻度窒息缺氧组（P〈0．01）和无窒息缺氧组（P〈0．01）。结论窒息缺氧时氧自由基的产生可能使新生儿黄疸减轻、高胆红素血症发生率降低。

Objective To observe the relationship between apneic hypoxia and neonatal jaundice. Methods Serum bilirublin was measured in 106 new borns of term birth, who were divided into 3 groups： mild, severe and non apneic hypoxia groups. Comparison was made among three groups. Results The incidence rates of hyperbilirubinemia were 28.6%, 14.7% and 46.7% in the three groups , respectively, with significant difference（P〈 0.05）, which was obviously lower in severe apneic hypoxia group than in non apneic hypoxia group（P〈0. 01）. Sreum bilirublin levels were （184.7±48.3） μmol/L,（153.2±48.9） μmol/L and（209.6±49.7） μmol/L in the three groups, respectively, which were lower in mild apneic bypoxia group than that in non apneic hypoxia group（P〈0. 05）, and which was apparently lower in severe apneic hypoxia group than that in mild apneic hypoxia group（P〈0.01） and non apneic hypoxia group（P〈0. 01）. Conclusion Oxygen free radicals induced by apneic hypoxia may decrease the incidence rate of hyperbilirubinemia and alleviate neonatal jaundice.