亚低温治疗重型颅脑损伤53例临床研究

目的探讨亚低温治疗重型颅脑损伤病人的作用及临床效果。方法共100例病人（昏迷GCS〈8分）随机分为亚低温治疗组53例，入院后尽快采用亚低温治疗，直肠温度控制在32℃～35℃，持续3～14天；对照组47例，常规治疗，直肠温度控制在36．5℃～37．5℃，两组病人均于伤后3个月时根据GOS评估法判断疗效。结果亚低温治疗组病人恢复良好率提高，病死率降低，预后显著改善，无严重并发症。结论亚低温具有肯定的脑保护作用，用于治疗急性重型颅脑损伤病人，效果显著，可降低死亡率，提高生存质量，无严重并发症。

Objective To study the mechanism and clinical results of mild hypothermia treatment in severe head injuries. Methods Total 110 cases （GCS〈8） were randomizely into two groups ：The mild hypothermia group were 53 cases, accepted mild hypothermia soon after admission. The reclaim to control at 36.5～37.5; The contrast group were 47 cases, accepted a routine treatment the reclaim temperature controlled at 36.5～37.5 .The results were evaluated with GOS at 3 months after trauma. Results The recovery rat were high, mortality were low, the prognosis were better and no severe complication in mild hypothermia group. Conclusion There were a defined cerebral proliction action of mild hypothermia method, it might be applied in severe head injured with obvious good result, decreased mortality, good life quality and no severe complication.